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CS-W001157 4
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1-Benzylpiperidin-3-amine

  • CAS No. 60407-35-4

  • Cat. No. CS-0141590
  • Purity≥98%
  • MDL No.MFCD04038444

*For research and further manufacturing use only, not for direct human use.

1-Benzylpiperidin-3-amine|CS-0141590

Structure of 60407-35-4

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General Information

  • CAS No. 60407-35-4
  • Cat. No. CS-0141590
  • Purity ≥98%
  • MDL No. MFCD04038444
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈N₂
  • Molecular Weight 190.28
  • Synonym(s) 3-AMINO-1-PHENYLMETHYLPIPERIDINE
  • SMILES NC1CN(CC2=CC=CC=C2)CCC1

Description

1-Benzylpiperidin-3-amine features a piperidine core functionalized with a benzyl group and a primary amine at the 3-position, enabling integration into bioactive molecule scaffolds. This structural motif imparts favorable solubility and metabolic stability, facilitating its use in medicinal chemistry campaigns targeting CNS disorders and receptor modulators.

Application

1-Benzylpiperidin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through standard functional group transformations. Its piperidine core offers favorable solubility and metabolic stability, while the benzyl and primary amine functionalities provide orthogonal handles for further derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for high-throughput synthesis and lead optimization campaigns.

Synthesis

  • Route1
    • 1-Benzylpiperidine-3-carbohydrazide|CS-0258569
      182919-58-0
    • ~79%
    • In-stock
      1-Benzylpiperidin-3-amine|CS-0141590
      60407-35-4

    References

    • Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
  • Route2
    • null|null
      100-39-0
    • ~%
    • In-stock
      1-Benzylpiperidin-3-amine|CS-0141590
      60407-35-4

    References

    • Tetrahedron Letters, , vol. 42, # 33 p. 5645 - 5649
  • Route3

    References

    • Tetrahedron Letters, , vol. 42, # 33 p. 5645 - 5649

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   1.6097
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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