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CS-W001157 4
Total: USD 88.00

4-Methylthiophene-2-carbaldehyde

  • CAS No. 6030-36-0

  • Cat. No. CS-0135491
  • Purity≥95%
  • MDL No.MFCD00159561

*For research and further manufacturing use only, not for direct human use.

4-Methylthiophene-2-carbaldehyde|CS-0135491

Structure of 6030-36-0

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General Information

  • CAS No. 6030-36-0
  • Cat. No. CS-0135491
  • Purity ≥95%
  • MDL No. MFCD00159561
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆OS
  • Molecular Weight 126.18
  • Synonym(s) 4-Methylthiophene-2-Carboxaldehyde
  • SMILES O=CC1=CC(C)=CS1

Description

4-Methylthiophene-2-carbaldehyde features a thiophene core with methyl and formyl substituents at the 4- and 2-positions, respectively. This configuration imparts enhanced electron density at the ring and a reactive aldehyde group amenable to nucleophilic addition. The molecule exhibits bench-stable handling characteristics and integrates readily into heterocyclic synthesis workflows, particularly in the construction of functionalized thienyl scaffolds for pharmaceutical and materials applications.

Application

4-Methylthiophene-2-carbaldehyde serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted thiophene derivatives via standard functional group transformations. Its aldehyde functionality facilitates condensation reactions, while the methyl-substituted thiophene core provides robust stability and compatibility with diverse reaction conditions. This compound functions effectively in coupling protocols and serves as a key intermediate in the construction of bioactive scaffolds and pharmaceutical candidates.

Synthesis

  • Route1
    • null|null
      616-44-4
    • null|null
      68-12-2
    • ~87%
    • In-stock
      4-Methylthiophene-2-carbaldehyde|CS-0135491
      6030-36-0

    References

    • SUNOVION PHARMACEUTICALS, INC.; PSYCHOGENICS INC.; SHAO, Liming; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; CAMPBELL, Una; HANANIA, Taleen, G. Patent: WO2011/69063 A2, 2011 ; Location in patent: Page/Page column 104 ;
  • Route2
    • null|null
      68-12-2
    • ~90%
    • In-stock
      4-Methylthiophene-2-carbaldehyde|CS-0135491
      6030-36-0

    References

    • BIOLIPOX AB Patent: WO2006/77412 A1, 2006 ; Location in patent: Page/Page column 76 ; WO 2006/077412 A1
  • Route3
    • null|null
      68-12-2
    • ~%
    • In-stock
      4-Methylthiophene-2-carbaldehyde|CS-0135491
      6030-36-0
    • In-stock
      3-Methyl-2-thiophenecarboxaldehyde ,tech|CS-0071758
      5834-16-2

    References

    • US2008/21026 A1, ; Page/Page column 17; 28 ; US 20080021026 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H302
Precautionary Statements : P210-P264-P270-P280-P330-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.86902
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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