Ethyl 5-amino-2-chloropyrimidine-4-carboxylate

Name: Ethyl 5-amino-2-chloropyrimidine-4-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 59950-50-4
Cat. No. CS-0042571
Purity≥95%
MDL No.MFCD22377545

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 5-amino-2-chloropyrimidine-4-carboxylate|CS-0042571

Structure of 59950-50-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 59950-50-4
Cat. No. CS-0042571
Purity ≥95%
MDL No. MFCD22377545
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈ClN₃O₂
Molecular Weight None
Synonym(s) 5-amino-2-chloro-pyrimidine-4-carboxylic acid ethyl ester
SMILES CCOC(=O)C1=C(N)C=NC(Cl)=N1

Description

Ethyl 5-amino-2-chloropyrimidine-4-carboxylate features a pyrimidine core bearing amino and chloro substituents at C5 and C2, respectively, with a carboxylate ester at C4. This electron-rich scaffold integrates readily into heterocyclic syntheses, serving as a key intermediate in medicinal chemistry due to its reactive functional groups and stability under standard conditions.

Application

Ethyl 5-amino-2-chloropyrimidine-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and coupling reactions. The amino and chloro groups offer orthogonal reactivity for sequential functionalization, while the ester moiety supports further transformations. Bench-stable and readily purified by recrystallization, it facilitates scalable synthesis of pharmaceutical intermediates and agrochemical candidates.

Synthesis

Route1
- In-stock
  
  54368-61-5
- ~%
- In-stock
  
  59950-50-4
References
- SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG Patent: WO2004/56826 A1, 2004 ; Location in patent: Page 74 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 78.1
LogP 0.8889
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

59950-50-4 sigma59950-50-4 manufacturer59950-50-4 price59950-50-4 structure59950-50-4 SDSbuy 59950-50-459950-50-4 supplier59950-50-4 uses59950-50-4 molecular weightprice of 59950-50-459950-50-4 chemical name formula of 59950-50-4

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Ethyl 5-amino-2-chloropyrimidine-4-carboxylate

CAS No. 59950-50-4

Recommended Products