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CS-W001157 4
Total: USD 88.00

2,3-Dichloro-5-methylpyridine

  • CAS No. 59782-90-0

  • Cat. No. CS-W013261
  • Purity≥97%
  • MDL No.MFCD08704667

*For research and further manufacturing use only, not for direct human use.

2,3-Dichloro-5-methylpyridine|CS-W013261

Structure of 59782-90-0

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General Information

  • CAS No. 59782-90-0
  • Cat. No. CS-W013261
  • Purity ≥97%
  • MDL No. MFCD08704667
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂N
  • Molecular Weight 162.01
  • Synonym(s) 2,5-Dichoro-3-picoline
  • SMILES CC1=CN=C(Cl)C(Cl)=C1

Description

2,3-Dichloro-5-methylpyridine is a chlorinated pyridine derivative featuring a methyl group at the 5-position and chlorine substituents at the 2- and 3-positions. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a key building block in medicinal chemistry and agrochemical synthesis. The steric and electronic profile supports selective functionalization under palladium catalysis.

Application

2,3-Dichloro-5-methylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of nitrogen-containing heterocycles. Its electrophilic character at the pyridine ring facilitates nucleophilic substitution under mild conditions, while the methyl group provides a handle for further functionalization. The compound exhibits good bench stability and compatibility with standard purification techniques, making it suitable for scalable synthetic workflows.

Synthesis

  • Route1
    • null|null
      27313-32-2
    • null|null
      107-13-1
    • ~53%
    • In-stock
      2,3-Dichloro-5-methylpyridine|CS-W013261
      59782-90-0

    References

    • Martin, Pierre; Steiner, Eginhard; Streith, Jacques; Winkler, Tammo; Bellus, Daniel Tetrahedron, 1985 , vol. 41, # 19 p. 4057 - 4078
  • Route2
    • null|null
      12775-96-1
    • null|null
      90044-00-1
    • ~%
    • In-stock
      2,3-Dichloro-5-methylpyridine|CS-W013261
      59782-90-0

    References

    • US4469896 A1, ;
  • Route3

    References

    • Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.69682
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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