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CS-W001157 4
Total: USD 88.00

2-(Thiophen-3-yl)ethanamine

  • CAS No. 59311-67-0

  • Cat. No. CS-0040873
  • Purity≥97%
  • MDL No.MFCD00176329

*For research and further manufacturing use only, not for direct human use.

2-(Thiophen-3-yl)ethanamine|CS-0040873

Structure of 59311-67-0

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General Information

  • CAS No. 59311-67-0
  • Cat. No. CS-0040873
  • Purity ≥97%
  • MDL No. MFCD00176329
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NS
  • Molecular Weight 127.21
  • Synonym(s) 2-thiophen-3-ylethanamine
  • SMILES NCCC1=CSC=C1

Description

2-(Thiophen-3-yl)ethanamine features a thiophene ring linked via an ethyl spacer to a primary amine, delivering a versatile scaffold for bioactive molecule synthesis. The electron-rich heterocycle enhances π-stacking potential, while the pendant amine enables facile derivatization. This bench-stable compound integrates readily into pharmaceutical intermediates and functional materials.

Application

2-(Thiophen-3-yl)ethanamine serves as a versatile building block for bioactive heterocycles, enabling direct incorporation of thiophene motifs into pharmaceutical scaffolds. Its primary amine functionality facilitates facile conjugation via amidation, alkylation, or reductive amination, while the thiophene ring imparts favorable electronic and metabolic properties. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis in medicinal chemistry campaigns.

Synthesis

  • Route1

    References

    • Saavedra, Jaime Z.; Resendez, Angel; Rovira, Alexander; Eagon, Scott; Haddenham, Dustin; Singaram, Bakthan Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 221 - 228
  • Route2
    • (e)-3-(2-Nitrovinyl)thiophene|CS-0686411
      110143-52-7
    • ~%
    • In-stock
      2-(Thiophen-3-yl)ethanamine|CS-0040873
      59311-67-0

    References

    • Journal of the American Chemical Society, , vol. 76, p. 4466
  • Route3
    • null|null
      34846-44-1
    • ~%
    • In-stock
      2-(Thiophen-3-yl)ethanamine|CS-0040873
      59311-67-0

    References

    • Journal of the American Chemical Society, , vol. 76, p. 4466

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.2493
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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