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CS-W001157 4
Total: USD 88.00

Butyl carbamate

  • CAS No. 592-35-8

  • Cat. No. CS-0152093
  • Purity≥98%
  • MDL No.MFCD00007967

*For research and further manufacturing use only, not for direct human use.

Butyl carbamate|CS-0152093

Structure of 592-35-8

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General Information

  • CAS No. 592-35-8
  • Cat. No. CS-0152093
  • Purity ≥98%
  • MDL No. MFCD00007967
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO₂
  • Molecular Weight 117.15
  • Synonym(s) Carbamic Acid Butyl Ester
  • SMILES CCCCOC(N)=O

Description

Butyl carbamate serves as a stable, moisture-tolerant protecting group for primary amines in synthetic workflows. This robust carbamate integrates seamlessly into peptide coupling sequences and offers reliable deprotection under mild acidic conditions. Its linear alkyl chain enhances solubility in common organic solvents while maintaining compatibility with diverse reaction environments.

Application

Butyl carbamate serves as a stable, bench-friendly carbamoyl protecting group for amines, enabling selective derivatization in peptide synthesis and medicinal chemistry. It exhibits excellent functional group tolerance and can be introduced under mild conditions, facilitating straightforward deprotection via acidolysis or catalytic hydrogenation. Its robustness and predictable reactivity make it a reliable choice for constructing complex nitrogen-containing scaffolds.

Synthesis

  • Route1

    References

    • US2010/312001 A1, ; Page/Page column 4 ;
  • Route2

    References

    • US2834799 , ;
  • Route3
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    • ~%
    • In-stock
      Butyl carbamate|CS-0152093
      592-35-8
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    References

    • Angewandte Chemie - International Edition, , vol. 46, # 27 p. 5184 - 5186

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.8818
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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