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CS-W001157 4
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5-Chlorothiazole-2-carbaldehyde

  • CAS No. 59129-52-1

  • Cat. No. CS-0050550
  • Purity≥96%
  • MDL No.MFCD08460383

*For research and further manufacturing use only, not for direct human use.

5-Chlorothiazole-2-carbaldehyde|CS-0050550

Structure of 59129-52-1

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General Information

  • CAS No. 59129-52-1
  • Cat. No. CS-0050550
  • Purity ≥96%
  • MDL No. MFCD08460383
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂ClNOS
  • Molecular Weight 147.58
  • Synonym(s) 5-CHLORO-2-THIAZOLECARBOXALDEHYDE
  • SMILES ClC1=CN=C(S1)C=O

Description

5-Chlorothiazole-2-carbaldehyde features a chlorinated thiazole ring fused to an aldehyde group, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient carbonyl serves as a key building block for pharmaceutical intermediates and functional materials, offering high reactivity under mild conditions. The molecule exhibits bench-stable handling with compatibility across diverse synthetic transformations.

Application

5-Chlorothiazole-2-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds. Its aldehyde functionality facilitates nucleophilic additions, reductive aminations, and coupling reactions, while the chlorine substituent supports further functionalization via cross-coupling or electrophilic substitution. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1
    • 5-Chloro-2-(1,3-dioxolan-2-yl)-1,3-thiazole|CS-0055314
      1080061-38-6
    • ~71%
    • In-stock
      5-Chlorothiazole-2-carbaldehyde|CS-0050550
      59129-52-1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2149550 A1, 2010 ; Location in patent: Page/Page column 125 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.609
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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