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1-Bromo-3-(3-bromopropoxy)propane

  • CAS No. 58929-72-9

  • Cat. No. CS-0526980
  • Purity≥95%
  • MDL No.MFCD22200244

*For research and further manufacturing use only, not for direct human use.

1-Bromo-3-(3-bromopropoxy)propane|CS-0526980

Structure of 58929-72-9

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General Information

  • CAS No. 58929-72-9
  • Cat. No. CS-0526980
  • Purity ≥95%
  • MDL No. MFCD22200244
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂Br₂O
  • Molecular Weight 259.97
  • Synonym(s) None
  • SMILES BrCCCOCCCBr

Description

1-Bromo-3-(3-bromopropoxy)propane features two reactive bromine atoms separated by a flexible ether linkage, enabling efficient coupling in multi-step syntheses. This bifunctional scaffold facilitates the construction of complex polyether architectures and serves as a key intermediate in the development of macrocyclic compounds and functionalized polymers under standard conditions.

Application

1-Bromo-3-(3-bromopropoxy)propane serves as a versatile dibrominated building block for the synthesis of bifunctional linkers and polyether architectures. Its terminal bromide groups enable sequential coupling reactions, facilitating the construction of symmetric or asymmetric spacer units in macrocyclic systems and functionalized polymers. The molecule exhibits good bench stability and compatibility with standard nucleophilic substitution protocols, allowing straightforward purification and integration into complex synthetic sequences.

Synthesis

  • Route1

    References

    • ESPERION THERAPEUTICS, INC. Patent: WO2005/68410 A1, 2005 ; Location in patent: Page/Page column 232; 240 ; WO 2005/068410 A1
  • Route2
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    • In-stock
      1-Bromo-3-(3-bromopropoxy)propane|CS-0526980
      58929-72-9

    References

    • Schnekenburger Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 12 p. 1853 - 1858
  • Route3

    References

    • Schnekenburger Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 12 p. 1853 - 1858

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.573
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   6

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