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Structure of 58458-13-2
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2-Bromo-6-(trifluoromethyl)aniline features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the bromine substituent enables facile cross-coupling transformations. This combination facilitates efficient integration into complex molecular architectures under standard conditions.
2-Bromo-6-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity profile. The bromo group facilitates efficient Suzuki, Stille, and Negishi couplings, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step syntheses of heterocyclic scaffolds and functionalized aromatic systems.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: