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CS-W001157 4
Total: USD 88.00

Lilolidine

  • CAS No. 5840-01-7

  • Cat. No. CS-B1108
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD09841910

*For research and further manufacturing use only, not for direct human use.

Lilolidine|CS-B1108

Structure of 5840-01-7

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General Information

  • CAS No. 5840-01-7
  • Cat. No. CS-B1108
  • Purity ≥97%
  • MDL No. MFCD09841910
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁N
  • Molecular Weight None
  • Synonym(s) Lilolidene; 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline
  • SMILES N12CCCC3=C1C(C=C2)=CC=C3

Description

Lilolidine is a nitrogen-containing heterocyclic compound featuring a saturated five-membered ring with two adjacent nitrogen atoms. This structure imparts enhanced basicity and solubility compared to analogous azacyclic systems. The molecule serves as a key scaffold in medicinal chemistry, particularly for designing bioactive molecules with improved metabolic stability and membrane permeability.

Application

Lilolidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of bioactive scaffolds. Its saturated pyrrolidine core exhibits excellent functional group tolerance and bench stability, facilitating downstream derivatization via standard amine alkylation, acylation, and reductive amination protocols. The molecule functions effectively in multistep syntheses requiring robust reaction conditions and clean purification profiles, making it a practical choice for API development and target-oriented synthesis.

Synthesis

  • Route1

    References

    • Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
  • Route2
    • null|null
      1220339-77-4
    • ~71%
    • In-stock
      Lilolidine|CS-B1108
      5840-01-7

    References

    • Shi, Zhuangzhi; Zhang, Chun; Li, Si; Pan, Delin; Ding, Shengtao; et al. Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4572 - 4576 Angewandte Chemie, 2009 , vol. 121, p. 4642 - 4646
  • Route3

    References

    • Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1826 - 1833

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   4.93
  • LogP   2.5875
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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