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CS-W001157 4
Total: USD 88.00

4H-1,2,4-Triazol-4-amine

  • CAS No. 584-13-4

  • Cat. No. CS-W019307
  • Purity≥97%
  • MDL No.MFCD00003099

*For research and further manufacturing use only, not for direct human use.

4H-1,2,4-Triazol-4-amine|CS-W019307

Structure of 584-13-4

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General Information

  • CAS No. 584-13-4
  • Cat. No. CS-W019307
  • Purity ≥97%
  • MDL No. MFCD00003099
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₄N₄
  • Molecular Weight 84.08
  • Synonym(s) 4H-1,2,4-triazol-4-ylamine; 4H-1,2,4-Triazol-4-amine
  • SMILES C1=NN=C[N]1N

Description

t-Boc-N-Amido-PEG3-amine is a PEG linker with an amino group and Boc-protected amino. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to free the amine.

Application

4H-1,2,4-Triazol-4-amine serves as a versatile building block in medicinal chemistry and catalysis, enabling the synthesis of triazole-based heterocycles via standard coupling protocols. Its high functional group tolerance and bench stability facilitate straightforward incorporation into complex molecular architectures, including API scaffolds and bioactive ligands.

Synthesis

  • Route1
    • null|null
      64-18-6
    • ~50%
    • In-stock
      4H-1,2,4-Triazol-4-amine|CS-W019307
      584-13-4

    References

    • Matulkova, Irena; Nemec, Ivan; Teubner, Karel; Nemec, Petr; Micka, Zdenek Journal of Molecular Structure, 2008 , vol. 873, # 1-3 p. 46 - 60
  • Route2
    • null|null
      7727-37-9
    • null|null
      109-94-4
    • ~%
    • In-stock
      4H-1,2,4-Triazol-4-amine|CS-W019307
      584-13-4

    References

    • US2005/165241 A1, ; Page/Page column 1-2 ;
  • Route3

    References

    • Journal of Chemical Research, Miniprint, , # 2 p. 514 - 529

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.73
  • LogP   -1.0081
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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