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7-Aminoquinolin-2(1H)-one

  • CAS No. 58336-33-7

  • Cat. No. CS-0312338
  • Purity≥97%
  • MDL No.MFCD16660969

*For research and further manufacturing use only, not for direct human use.

7-Aminoquinolin-2(1H)-one|CS-0312338

Structure of 58336-33-7

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General Information

  • CAS No. 58336-33-7
  • Cat. No. CS-0312338
  • Purity ≥97%
  • MDL No. MFCD16660969
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) 7-AMino-1H-quinolin-2-one
  • SMILES O=C1NC2=C(C=CC(N)=C2)C=C1

Description

7-Aminoquinolin-2(1H)-one delivers a versatile heterocyclic scaffold with enhanced solubility and stability under standard conditions. The amino group at the 7-position enables direct functionalization, while the quinolinone core provides a rigid, planar framework ideal for conjugation. This compound serves as a key intermediate in medicinal chemistry, particularly for developing kinase inhibitors and fluorescent probes.

Application

7-Aminoquinolin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of quinoline-based scaffolds through standard coupling and functionalization reactions. Its amine and carbonyl functionalities offer orthogonal reactivity for peptide conjugation, derivatization, and metal-catalyzed transformations. Bench-stable and readily purified by crystallization or column chromatography, it functions effectively in both solution-phase and solid-phase synthesis workflows.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 60, p. 2104
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 60, p. 2104
  • Route3
    • null|null
      85818-66-2
    • ~%
    • In-stock
      7-Aminoquinolin-2(1H)-one|CS-0312338
      58336-33-7

    References

    • Monatshefte fuer Chemie, , vol. 23, p. 535

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.88
  • LogP   1.1103
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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