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CS-W001157 4
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6-(3-Fluorophenyl)nicotinic acid

  • CAS No. 582325-22-2

  • Cat. No. CS-0156904
  • Molecule weight217.20
  • Purity≥98%
  • MDL No.MFCD06410387

*For research and further manufacturing use only, not for direct human use.

6-(3-Fluorophenyl)nicotinic acid|CS-0156904

Structure of 582325-22-2

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General Information

  • CAS No. 582325-22-2
  • Cat. No. CS-0156904
  • Purity ≥98%
  • MDL No. MFCD06410387
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈FNO₂
  • Molecular Weight 217.20
  • Synonym(s) 6-(3-Fluorophenyl)-nicotinic acid
  • SMILES C1=CC(=CC(=C1)F)C2=NC=C(C=C2)C(=O)O

Description

6-(3-Fluorophenyl)nicotinic acid features a fluorinated phenyl ring directly attached to the nicotinic acid scaffold, enhancing electron-withdrawal and metabolic stability. This substitution pattern imparts favorable pharmacokinetic properties and enables direct incorporation into bioactive heterocycles for medicinal chemistry applications.

Application

6-(3-Fluorophenyl)nicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its structure combines a pyridine core with an electron-deficient 3-fluorophenyl substituent, enabling efficient coupling reactions via Suzuki, Stille, or direct arylation. The carboxylic acid functionality facilitates derivatization into amides, esters, or acyl chlorides, supporting downstream functionalization in medicinal chemistry campaigns. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.5859
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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