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CS-W001157 4
Total: USD 88.00

2-Hydroxy-6-naphthol

  • CAS No. 581-43-1

  • Cat. No. CS-0059281
  • Purity≥98%
  • MDL No.MFCD00004082

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-6-naphthol|CS-0059281

Structure of 581-43-1

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General Information

  • CAS No. 581-43-1
  • Cat. No. CS-0059281
  • Purity ≥98%
  • MDL No. MFCD00004082
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈O₂
  • Molecular Weight 160.17
  • Synonym(s) naphthalene-2,6-diol
  • SMILES OC1=CC2=CC=C(O)C=C2C=C1

Description

2,6-Dihydroxynaphthalene was used in the synthesis of 1,5-dichloro-2,6-diethynylnaphthalenes. It was also used in the preparation of first-generation rotaxane dendrimer.

Application

2-Hydroxy-6-naphthol serves as a versatile building block in the synthesis of functionalized naphthalene derivatives, leveraging its ortho-hydroxy substitution for directed metallation and electrophilic functionalization. The phenolic hydroxyl group enables facile protection and participation in coupling reactions, while the rigid aromatic core supports applications in dye intermediates and pharmaceutical scaffolds. Bench-stable and amenable to standard purification techniques, it functions reliably in multistep synthetic sequences requiring regioselective transformations.

Synthesis

  • Route1
    • In-stock
      2,6-Diisopropylnaphthalene|CS-W014993
      24157-81-1
    • ~93%
    • In-stock
      2-Hydroxy-6-naphthol|CS-0059281
      581-43-1
    • null|null
      91909-30-7

    References

    • Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 199 - 202
  • Route2

    References

    • Hwu, Jih Ru; Tsay, Shwu-Chen Journal of Organic Chemistry, 1990 , vol. 55, # 24 p. 5987 - 5991
  • Route3
    • Naphthalene-2,6-diyl diacetate|CS-0449899
      22426-47-7
    • ~0%
    • In-stock
      2-Hydroxy-6-naphthol|CS-0059281
      581-43-1
    • null|null
      125363-65-7

    References

    • Ciuffreda, Pierangela; Casati, Silvana; Santaniello, Enzo Tetrahedron, 2000 , vol. 56, # 2 p. 317 - 321

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   2.251
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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