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CS-W001157 4
Total: USD 88.00

4-(Prop-2-yn-1-yl)morpholine

  • CAS No. 5799-76-8

  • Cat. No. CS-D1616
  • Purity≥98%
  • MDL No.MFCD00510919

*For research and further manufacturing use only, not for direct human use.

4-(Prop-2-yn-1-yl)morpholine|CS-D1616

Structure of 5799-76-8

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General Information

  • CAS No. 5799-76-8
  • Cat. No. CS-D1616
  • Purity ≥98%
  • MDL No. MFCD00510919
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁NO
  • Molecular Weight 125.17
  • Synonym(s) 4-(2-Propyn-1-yl)morpholine; 3-(4-Morpholinyl)-1-propyne; 3-(N-Morpholinyl)propyne; 3-Morpholino-1-propyne; 4-Propargylmorpholine
  • SMILES C#CCN1CCOCC1

Description

4-(Prop-2-yn-1-yl)morpholine is a versatile synthetic intermediate featuring a reactive terminal alkyne group appended to a morpholine ring. This structure enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and click chemistry applications. The molecule exhibits excellent solubility in common organic solvents and maintains stability under standard bench conditions, facilitating straightforward handling in process development workflows.

Application

4-(Prop-2-yn-1-yl)morpholine serves as a versatile building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The terminal alkyne functionality offers high reactivity and compatibility with standard click chemistry protocols, while the morpholine ring provides favorable solubility and metabolic stability. Bench-stable and readily purified by silica gel chromatography, it functions reliably in multi-step syntheses requiring orthogonal functional group handling.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   -0.0482
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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