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CS-W001157 4
Total: USD 88.00

2-Acetylbenzoic acid

  • CAS No. 577-56-0

  • Cat. No. CS-0017379
  • Purity≥98%
  • MDL No.MFCD00002475

*For research and further manufacturing use only, not for direct human use.

2-Acetylbenzoic acid|CS-0017379

Structure of 577-56-0

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General Information

  • CAS No. 577-56-0
  • Cat. No. CS-0017379
  • Purity ≥98%
  • MDL No. MFCD00002475
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₃
  • Molecular Weight 164.16
  • Synonym(s) None
  • SMILES O=C(C1=C(C(C)=O)C=CC=C1)O

Description

Fmoc-N-amido-PEG3-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Synthesis

  • Route1
    • null|null
      85-44-9
    • null|null
      141-82-2
    • ~68%
    • In-stock
      2-Acetylbenzoic acid|CS-0017379
      577-56-0

    References

    • GLAXO GROUP LIMITED; DWYER, Andrew Neil; GORDON, Andrew; URQUHART, Michael Patent: WO2012/80243 A2, 2012 ; Location in patent: Page/Page column 15 ;
  • Route2

    References

    • Lesma, Giordano; Sacchetti, Alessandro; Silvani, Alessandra Synthesis, 2006 , # 4 p. 594 - 596
  • Route3
    • In-stock
      2-Methylacetophenone|CS-W013374
      577-16-2
    • ~%
    • In-stock
      2-Acetylbenzoic acid|CS-0017379
      577-56-0
    • null|null
      1828-76-8

    References

    • Advanced Synthesis and Catalysis, , vol. 351, # 10 p. 1677 - 1684

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.5874
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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