4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-amine

Name: 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 57688-34-3
Cat. No. CS-0157576
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-amine|CS-0157576

Structure of 57688-34-3

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General Information

CAS No. 57688-34-3
Cat. No. CS-0157576
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₀F₃N
Molecular Weight 237.22
Synonym(s) 4'-(Trifluoromethyl)-biphenyl-4-amine
SMILES C1=C(C=CC(=C1)C(F)(F)F)C2=CC=C(C=C2)N

Description

4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-amine features a trifluoromethyl group at the para position of one phenyl ring, imparting strong electron-withdrawing character and enhanced metabolic stability. This aryl amine integrates readily into conjugated systems, enabling efficient coupling in cross-coupling reactions and serving as a key building block for functional materials and bioactive compounds.

Application

4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-amine serves as a versatile building block in the synthesis of functionalized biaryl scaffolds. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the primary amine enables straightforward coupling reactions. The compound exhibits excellent bench stability and compatibility with standard cross-coupling protocols, facilitating efficient access to complex pharmaceutical intermediates and advanced materials.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 26.02
LogP 3.9546
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-amine

CAS No. 57688-34-3

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