Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Chloro-5-nitro-1H-imidazole

  • CAS No. 57531-37-0

  • Cat. No. CS-W018201
  • Purity≥97%
  • MDL No.MFCD08705680

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-nitro-1H-imidazole|CS-W018201

Structure of 57531-37-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 57531-37-0
  • Cat. No. CS-W018201
  • Purity ≥97%
  • MDL No. MFCD08705680
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂ClN₃O₂
  • Molecular Weight 147.52
  • Synonym(s) 2-Chloro-4-nitro-1H-imidazole
  • SMILES O=[N+](C1=CN=C(Cl)N1)[O-]

Description

2-chloro-5-nitro-1H-imidazole features a fused five-membered ring bearing chlorine and nitro groups at adjacent positions, conferring high electrophilicity and stability under standard conditions. This configuration enables direct coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring electron-deficient heterocycles.

Application

2-Chloro-5-nitro-1H-imidazole serves as a versatile building block for the synthesis of functionalized imidazole scaffolds, enabling direct substitution at C2 and electrophilic functionalization at C4. Its dual electron-withdrawing groups enhance regioselective reactivity in palladium-catalyzed couplings and nucleophilic aromatic substitution reactions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1
    • null|null
      683276-67-7
    • ~99%
    • In-stock
      2-Chloro-5-nitro-1H-imidazole|CS-W018201
      57531-37-0

    References

    • OTSUKA PHARMACEUTICAL CO., LTD. Patent: WO2005/77913 A1, 2005 ; Location in patent: Page/Page column 76-77 ;
  • Route2
    • null|null
      683276-47-3
    • ~75%
    • In-stock
      2-Chloro-5-nitro-1H-imidazole|CS-W018201
      57531-37-0

    References

    • OTSUKA PHARMACEUTICAL CO., LTD. Patent: WO2006/35960 A2, 2006 ; Location in patent: Page/Page column 17 ;
  • Route3

    References

    • Otsuka Pharmaceutical Company, Limited Patent: EP1553088 A1, 2005 ; Location in patent: Page/Page column 58 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   71.82
  • LogP   0.9713
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Chloro-5-nitro-1H-imidazole sigma2-Chloro-5-nitro-1H-imidazole manufacturer2-Chloro-5-nitro-1H-imidazole price2-Chloro-5-nitro-1H-imidazole structure2-Chloro-5-nitro-1H-imidazole SDSbuy 2-Chloro-5-nitro-1H-imidazole2-Chloro-5-nitro-1H-imidazole supplier2-Chloro-5-nitro-1H-imidazole uses2-Chloro-5-nitro-1H-imidazole molecular weightprice of 2-Chloro-5-nitro-1H-imidazole2-Chloro-5-nitro-1H-imidazole chemical name formula of 2-Chloro-5-nitro-1H-imidazole
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label