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CS-W001157 4
Total: USD 88.00

Benzyl 2-(dimethoxyphosphoryl)acetate

  • CAS No. 57443-18-2

  • Cat. No. CS-0199168
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzyl 2-(dimethoxyphosphoryl)acetate|CS-0199168

Structure of 57443-18-2

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General Information

  • CAS No. 57443-18-2
  • Cat. No. CS-0199168
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅O₅P
  • Molecular Weight 258.21
  • Synonym(s) Dimethylphosphonoacetic Acid Benzyl Ester
  • SMILES COP(=O)(CC(=O)OCC1=CC=CC=C1)OC

Description

Benzyl 2-(dimethoxyphosphoryl)acetate features a dimethoxyphosphoryl group that enables direct incorporation into phosphonate-containing architectures. This stable, bench-ready reagent facilitates efficient P–C bond formation in synthetic sequences. The benzyl ester moiety offers straightforward deprotection under standard conditions, enabling rapid access to functionalized intermediates.

Application

Benzyl 2-(dimethoxyphosphoryl)acetate serves as a versatile synthon in carbonyl-alkylation and phosphonate-mediated C–C bond formation. Its stabilized α-phosphono ester structure enables reliable Michael additions, Mannich reactions, and Horner–Wadsworth–Emmons olefination with high functional group tolerance. The benzyl ester facilitates straightforward deprotection under mild hydrogenolysis conditions, offering efficient access to key intermediates for heterocyclic synthesis and pharmaceutical building blocks.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   2.2157
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   6

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