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CS-W001157 4
Total: USD 88.00

2-Methoxy-4-methylbenzaldehyde

  • CAS No. 57415-35-7

  • Cat. No. CS-W021710
  • Purity≥95%
  • MDL No.MFCD06248007

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-methylbenzaldehyde|CS-W021710

Structure of 57415-35-7

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General Information

  • CAS No. 57415-35-7
  • Cat. No. CS-W021710
  • Purity ≥95%
  • MDL No. MFCD06248007
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.17
  • Synonym(s) 4-Methyl-6-methoxybenzaldehyde
  • SMILES O=CC1=CC=C(C)C=C1OC

Description

2-Methoxy-4-methylbenzaldehyde features a benzaldehyde core functionalized with a methoxy group at the ortho position and a methyl group at the para position, delivering enhanced electron density and stability. This combination enables efficient incorporation into synthetic pathways requiring tailored aromatic aldehydes. The compound exhibits favorable solubility in common organic solvents and maintains bench-stable integrity under standard conditions.

Application

2-Methoxy-4-methylbenzaldehyde serves as a versatile aromatic building block in medicinal chemistry and agrochemical synthesis. Its ortho-methoxy and para-methyl substituents provide favorable electronic and steric profiles, enhancing reactivity in electrophilic substitution and coupling reactions. The aldehyde functionality enables efficient imine formation, reductive amination, and use in Ullmann or Suzuki-type cross-couplings. Bench-stable and readily purified by recrystallization, it functions as a key intermediate for heterocyclic scaffolds and functionalized aromatic systems.

Synthesis

  • Route1

    References

    • Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740
  • Route2

    References

    • Hauser, Frank M.; Ellenberger, Suzanne R. Synthesis, 1987 , # 8 p. 723 - 724
  • Route3
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    • In-stock
      2-Methoxy-4-methylbenzaldehyde|CS-W021710
      57415-35-7

    References

    • Journal of the American Chemical Society, , vol. 110, p. 7828

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.81612
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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