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CS-W001157 4
Total: USD 88.00

3-Bromo-4-chlorotoluene

  • CAS No. 57310-39-1

  • Cat. No. CS-W002337
  • Purity≥98%
  • MDL No.MFCD00079710

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-chlorotoluene|CS-W002337

Structure of 57310-39-1

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General Information

  • CAS No. 57310-39-1
  • Cat. No. CS-W002337
  • Purity ≥98%
  • MDL No. MFCD00079710
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrCl
  • Molecular Weight 205.48
  • Synonym(s) 2-Bromo-1-chloro-4-methylbenzene; 3-Bromo-4-chlorotoluene
  • SMILES Cc1ccc(c(c1)Br)Cl

Description

3-Bromo-4-chlorotoluene features a strategically positioned bromo and chloro substituent on the toluene ring, enabling selective cross-coupling reactions in transition-metal-catalyzed transformations. This electron-deficient aromatic scaffold delivers high reactivity under standard conditions while maintaining bench-stable handling properties.

Application

3-Bromo-4-chlorotoluene serves as a versatile aryl building block in cross-coupling reactions, enabling efficient construction of biaryl scaffolds under palladium-catalyzed conditions. Its complementary halogenation pattern offers orthogonal reactivity for sequential functionalization, while the methyl group provides a handle for further oxidation or side-chain elaboration. Bench-stable and readily purified by distillation, it supports scalable synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      106-43-4
    • ~1%
    • In-stock
      3-Bromo-4-chlorotoluene|CS-W002337
      57310-39-1
    • In-stock
      1-(Bromomethyl)-4-chlorobenzene|CS-0017948
      622-95-7

    References

    • Tetrahedron Letters, , vol. 48, # 18 p. 3247 - 3250
  • Route2
    • null|null
      106-43-4
    • ~%
    • In-stock
      3-Bromo-4-chlorotoluene|CS-W002337
      57310-39-1

    References

    • Journal of the Chemical Society, , vol. 105, p. 1910
  • Route3

    References

    • Journal of the Indian Chemical Society, , vol. 36, p. 329,333

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.41092
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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