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CS-W001157 4
Total: USD 88.00

3-Methylcyclobutanecarboxylic acid

  • CAS No. 57252-83-2

  • Cat. No. CS-W006107
  • Purity≥97%
  • MDL No.MFCD01734189

*For research and further manufacturing use only, not for direct human use.

3-Methylcyclobutanecarboxylic acid|CS-W006107

Structure of 57252-83-2

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General Information

  • CAS No. 57252-83-2
  • Cat. No. CS-W006107
  • Purity ≥97%
  • MDL No. MFCD01734189
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(C1CC(C)C1)O

Description

3-Methylcyclobutanecarboxylic acid features a strained cyclobutane ring with a methyl substituent that modulates reactivity and steric profile. This structural motif delivers enhanced rigidity and controlled functionalization potential, enabling efficient incorporation into bioactive scaffolds and synthetic intermediates under standard conditions.

Application

3-Methylcyclobutanecarboxylic acid serves as a valuable scaffold in medicinal chemistry and synthetic organic research, offering a rigid, substituted cyclobutane core with defined stereochemistry. Its carboxylic acid functionality enables straightforward derivatization via amide, ester, or acyl chloride formation, while the methyl substituent provides steric modulation and enhanced metabolic stability. The compound exhibits good bench stability and is compatible with standard coupling reactions, facilitating integration into complex molecular architectures such as bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • 3-Methylcyclobut-1-ene-1-carboxylic acid|CS-0541007
      89533-69-7
    • ~%
    • In-stock
      3-Methylcyclobutanecarboxylic acid|CS-W006107
      57252-83-2

    References

    • Journal of Organic Chemistry, , vol. 29, p. 801 - 812
  • Route2
    • null|null
      3280-19-1
    • ~%
    • In-stock
      3-Methylcyclobutanecarboxylic acid|CS-W006107
      57252-83-2

    References

    • Journal of Organic Chemistry, , vol. 29, p. 801 - 812
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 2723,2725

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.1171
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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