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CS-W001157 4
Total: USD 88.00

1-Methyl-4-(6-aminopyridin-3-yl)piperazine

  • CAS No. 571189-49-6

  • Cat. No. CS-M3136
  • Purity≥98%
  • MDL No.MFCD10009563

*For research and further manufacturing use only, not for direct human use.

1-Methyl-4-(6-aminopyridin-3-yl)piperazine|CS-M3136

Structure of 571189-49-6

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General Information

  • CAS No. 571189-49-6
  • Cat. No. CS-M3136
  • Purity ≥98%
  • MDL No. MFCD10009563
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆N₄
  • Molecular Weight 192.26
  • Synonym(s) 5-(4-Methylpiperazin-1-yl)pyridin-2-ylamine
  • SMILES NC1=NC=C(N2CCN(C)CC2)C=C1

Description

1-Methyl-4-(6-aminopyridin-3-yl)piperazine features a pyridine nitrogen flanked by an electron-rich piperazine ring, enabling strong hydrogen bonding and coordination in metal complexes. This scaffold integrates readily into bioactive molecules due to its polar surface area and moderate lipophilicity, supporting membrane permeability and solubility under standard conditions.

Application

1-Methyl-4-(6-aminopyridin-3-yl)piperazine serves as a versatile building block in medicinal chemistry, enabling rapid access to bioactive heterocyclic scaffolds. The primary amine group facilitates conjugation and derivatization, while the piperazine core offers favorable solubility and metabolic stability. Its bench-stable nature and compatibility with standard coupling reactions make it well-suited for parallel synthesis and lead optimization campaigns.

Synthesis

  • Route1

    References

    • US2005/38078 A1, ; Page/Page column 29 ; US 20050038078 A1
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 53, # 22 p. 7938 - 7957
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 53, # 22 p. 7938 - 7957

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.39
  • LogP   0.4156
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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