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CS-W001157 4
Total: USD 88.00

2-Fluorobenzimidamide hydrochloride

  • CAS No. 57075-81-7

  • Cat. No. CS-0019235
  • Purity≥97%
  • MDL No.MFCD04114435

*For research and further manufacturing use only, not for direct human use.

2-Fluorobenzimidamide hydrochloride|CS-0019235

Structure of 57075-81-7

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General Information

  • CAS No. 57075-81-7
  • Cat. No. CS-0019235
  • Purity ≥97%
  • MDL No. MFCD04114435
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClFN₂
  • Molecular Weight 174.60
  • Synonym(s) 2-Fluorobenzenecarboximidamide hydrochloride
  • SMILES N=C(C1=CC=CC=C1F)N.[H]Cl

Description

2-Fluorobenzimidamide hydrochloride offers a fluorinated benzimidazole scaffold with enhanced solubility and stability under standard conditions. This compound integrates a polar amide group flanked by electron-deficient aromatic character, enabling direct use in medicinal chemistry workflows without requiring prior activation.

Application

2-Fluorobenzimidamide hydrochloride serves as a key building block for fluorinated benzimidazole scaffolds, enabling direct incorporation of both amide and imine functionalities in medicinal chemistry workflows. Its crystalline form offers excellent bench stability and ease of handling, while the hydrochloride salt enhances solubility in polar solvents, facilitating downstream transformations such as cyclizations, cross-couplings, and nucleophilic substitutions under standard reaction conditions.

Synthesis

  • Route1
    • null|null
      394-47-8
    • ~81%
    • In-stock
      2-Fluorobenzimidamide hydrochloride|CS-0019235
      57075-81-7

    References

    • Dalai, Suryakanta; Belov, Vladimir N.; Nizamov, Shamil; Rauch, Karsten; Finsinger, Dirk; De Meijere, Armin European Journal of Organic Chemistry, 2006 , # 12 p. 2753 - 2765
  • Route2
    • null|null
      394-47-8
    • null|null
      4039-32-1
    • ~%
    • In-stock
      2-Fluorobenzimidamide hydrochloride|CS-0019235
      57075-81-7

    References

    • US6265426 B1, ; US 6265426 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.87
  • LogP   1.53157
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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