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CS-W001157 4
Total: USD 88.00

3-Methoxy-2-methylbenzaldehyde

  • CAS No. 56724-03-9

  • Cat. No. CS-0153510
  • Purity≥97%
  • MDL No.MFCD11044581

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-2-methylbenzaldehyde|CS-0153510

Structure of 56724-03-9

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General Information

  • CAS No. 56724-03-9
  • Cat. No. CS-0153510
  • Purity ≥97%
  • MDL No. MFCD11044581
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.17
  • Synonym(s) 3-Methoxy-2-methylbenzladehyde
  • SMILES CC1=C(C=CC=C1OC)C=O

Description

3-Methoxy-2-methylbenzaldehyde features a benzaldehyde core substituted with a methoxy group at the meta position and a methyl group ortho to the aldehyde. This electron-rich aromatic scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in synthesizing bioactive molecules and ligands for transition metal catalysis.

Application

3-Methoxy-2-methylbenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a well-defined ortho-substituted aromatic aldehyde scaffold. Its methoxy and methyl groups provide predictable electronic and steric modulation, enabling reliable coupling reactions, reductive aminations, and heterocycle formation. Bench-stable and readily purified by distillation or column chromatography, it functions efficiently in standard synthetic workflows requiring functional group tolerance and reproducible reactivity.

Synthesis

  • Route1

    References

    • Wyeth Patent: US2007/203116 A1, 2007 ; Location in patent: Page/Page column 8 ; US 20070203116 A1
  • Route2
    • In-stock
      m-Anisaldehyde|CS-W007346
      591-31-1
    • null|null
      74-88-4
    • ~85%
    • In-stock
      3-Methoxy-2-methylbenzaldehyde|CS-0153510
      56724-03-9

    References

    • Wang, Junhua; Pettus, Liping H.; Pettus, Thomas R. R. Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1793 - 1796
  • Route3
    • null|null
      72623-18-8
    • ~95%
    • In-stock
      3-Methoxy-2-methylbenzaldehyde|CS-0153510
      56724-03-9

    References

    • Leed, Andrew R.; Boettger, Susan D.; Ganem, Bruce Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 1098 - 1106

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.81612
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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