Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,6-Dimethyl-1H-indole

  • CAS No. 5649-36-5

  • Cat. No. CS-0036750
  • Molecule weight145.20
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,6-Dimethyl-1H-indole|CS-0036750

Structure of 5649-36-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 5649-36-5
  • Cat. No. CS-0036750
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁N
  • Molecular Weight 145.20
  • Synonym(s) 1H-Indole, 2,6-dimethyl-
  • SMILES CC1=CC2=C(C=C1)C=C(C)N2

Description

2,6-Dimethyl-1H-indole features a sterically hindered indole core with methyl groups at the 2 and 6 positions, enhancing stability and modulating electronic properties. This substitution pattern reduces reactivity at the aromatic ring while preserving the nitrogen lone pair for coordination or functionalization. The molecule exhibits favorable solubility in organic solvents and serves as a robust scaffold in synthetic applications requiring controlled reactivity and defined steric profiles.

Application

2,6-Dimethyl-1H-indole serves as a valuable building block in medicinal chemistry and heterocyclic synthesis, offering enhanced stability and defined regiochemistry due to methyl substitution at the 2- and 6-positions. Its electron-rich indole core facilitates electrophilic aromatic substitution and acts as a scaffold for C–H functionalization, enabling efficient access to complex alkaloid-like structures. The compound exhibits good bench stability, ease of handling, and compatibility with standard purification methods, making it well-suited for iterative synthetic campaigns in API development and target-oriented synthesis.

Synthesis

  • Route1
    • N-(2,5-Dimethylphenyl)acetamide|CS-0281034
      2050-44-4
    • ~5%
    • In-stock
      2,6-Dimethyl-1H-indole|CS-0036750
      5649-36-5

    References

    • Pirrung, Michael C.; Deng, Liu; Li, Zhitao; Park, Kaapjoo Journal of Organic Chemistry, 2002 , vol. 67, # 24 p. 8374 - 8388
  • Route2
    • In-stock
      2-Bromo-5-methylaniline|CS-W007555
      53078-85-6
    • null|null
      67-64-1
    • ~%
    • In-stock
      2,6-Dimethyl-1H-indole|CS-0036750
      5649-36-5

    References

    • Bard, Raymond R.; Bunnett, Joseph F. Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1546 - 1547
  • Route3
    • null|null
      93721-34-7
    • ~%
    • In-stock
      2,6-Dimethyl-1H-indole|CS-0036750
      5649-36-5

    References

    • Quelet; Chastrette Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1959 , vol. 249, p. 1526

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.78474
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,6-Dimethyl-1H-indole sigma2,6-Dimethyl-1H-indole manufacturer2,6-Dimethyl-1H-indole price2,6-Dimethyl-1H-indole structure2,6-Dimethyl-1H-indole SDSbuy 2,6-Dimethyl-1H-indole2,6-Dimethyl-1H-indole supplier2,6-Dimethyl-1H-indole uses2,6-Dimethyl-1H-indole molecular weightprice of 2,6-Dimethyl-1H-indole2,6-Dimethyl-1H-indole chemical name formula of 2,6-Dimethyl-1H-indole
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label