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CS-W001157 4
Total: USD 88.00

4-Chloro-2-fluorobenzyl alcohol

  • CAS No. 56456-49-6

  • Cat. No. CS-W002423
  • Purity≥96%
  • MDL No.MFCD00143285

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-fluorobenzyl alcohol|CS-W002423

Structure of 56456-49-6

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General Information

  • CAS No. 56456-49-6
  • Cat. No. CS-W002423
  • Purity ≥96%
  • MDL No. MFCD00143285
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClFO
  • Molecular Weight 160.57
  • Synonym(s) Benzenemethanol, 4-chloro-2-fluoro-
  • SMILES OCc1ccc(cc1F)Cl

Description

4-Chloro-2-fluorobenzyl alcohol features a benzyl alcohol scaffold with strategically positioned chlorine and fluorine substituents, delivering enhanced electronic and steric properties. This bench-stable compound integrates readily into synthetic routes requiring polar, electron-deficient aryl handles.

Application

4-Chloro-2-fluorobenzyl alcohol serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard functional group transformations. Its ortho-fluoro and para-chloro substituents provide enhanced metabolic stability and modulate electronic properties, while the benzylic alcohol facilitates derivatization via oxidation, protection, or coupling reactions. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multistep syntheses of pharmaceutical intermediates and agrochemicals.

Synthesis

  • Route1

    References

    • Viamet Pharmaceuticals, Inc. Patent: US2012/329788 A1, 2012 ; Location in patent: Page/Page column 22 ;
  • Route2

    References

    • Kelly, Stephen M.; Schad, Hanspeter Helvetica Chimica Acta, 1985 , vol. 68, p. 1444 - 1452
  • Route3

    References

    • Helvetica Chimica Acta, , vol. 68, p. 1444 - 1452

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.9714
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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