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CS-W001157 4
Total: USD 88.00

2-Propenoic acid, 3-cyclohexyl-, (2E)-

  • CAS No. 56453-86-2

  • Cat. No. CS-0031387
  • Purity≥96%
  • MDL No.MFCD03002774
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Propenoic acid, 3-cyclohexyl-, (2E)-|CS-0031387

Structure of 56453-86-2

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Description

(E)-3-Cyclohexylacrylic acid is a sterically defined, bench-stable α,β-unsaturated carboxylic acid featuring a conjugated trans double bond. This configuration enhances its utility in Michael additions and Diels-Alder reactions, where geometric control is critical. The cyclohexyl group imparts hydrophobic character and conformational rigidity, enabling precise spatial positioning in synthetic intermediates. Its moisture-tolerant stability simplifies handling under standard laboratory conditions.

Application

(E)-3-Cyclohexylacrylic acid serves as a versatile building block for synthesizing α,β-unsaturated carboxylic acids and their derivatives. Its conjugated double bond enables reliable Michael additions, Diels–Alder reactions, and palladium-catalyzed couplings. The cyclohexyl group imparts steric bulk and lipophilicity, enhancing metabolic stability in bioactive molecule design. Bench-stable and readily purified by recrystallization, it functions effectively in standard organic transformations.

General Information

  • CAS No. 56453-86-2
  • Cat. No. CS-0031387
  • Purity ≥96%
  • MDL No. MFCD03002774
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄O₂
  • Molecular Weight 154.21
  • Synonym(s) NSC 147133; (2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID
  • SMILES O=C(/C=C/C1CCCCC1)O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.2075
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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