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CS-W001157 4
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4-[(4-Fluorobenzyl)oxy]benzaldehyde

  • CAS No. 56442-17-2

  • Cat. No. CS-0116525
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-[(4-Fluorobenzyl)oxy]benzaldehyde|CS-0116525

Structure of 56442-17-2

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General Information

  • CAS No. 56442-17-2
  • Cat. No. CS-0116525
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₁FO₂
  • Molecular Weight 230.23
  • Synonym(s) 4-(4-Fluorobenzyloxy)benzaldehyde
  • SMILES O=CC1=CC=C(OCC2=CC=C(F)C=C2)C=C1

Description

4-[(4-Fluorobenzyl)oxy]benzaldehyde features a fluorinated benzyl ether linkage attached to a para-substituted benzaldehyde scaffold. This electron-deficient aldehyde integrates readily into coupling reactions, offering enhanced solubility and stability under standard bench conditions. The para-fluorophenyl moiety provides a tunable handle for further functionalization in synthetic medicinal chemistry workflows.

Application

4-[(4-Fluorobenzyl)oxy]benzaldehyde serves as a versatile bifunctional building block in medicinal chemistry, combining a reactive aldehyde group with a stable ether-linked fluorinated benzyl moiety. Its structure enables straightforward derivatization via reductive amination, condensation, or Suzuki coupling, while the 4-fluorophenyl substituent enhances metabolic stability and modulates lipophilicity. The compound exhibits excellent bench stability and is readily purified by silica gel chromatography, making it well-suited for scalable synthesis of bioactive heterocycles and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   3.2172
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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