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CS-W001157 4
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4-(1,4-Dioxaspiro[4.5]decan-8-yl)cyclohexanone

  • CAS No. 56309-94-5

  • Cat. No. CS-W014148
  • Molecule weight238.33
  • Purity≥97%
  • MDL No.MFCD00809704

*For research and further manufacturing use only, not for direct human use.

4-(1,4-Dioxaspiro[4.5]decan-8-yl)cyclohexanone|CS-W014148

Structure of 56309-94-5

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General Information

  • CAS No. 56309-94-5
  • Cat. No. CS-W014148
  • Purity ≥97%
  • MDL No. MFCD00809704
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₂O₃
  • Molecular Weight 238.33
  • Synonym(s) Dicyclohexane-4,4'dione monoethylene ketal
  • SMILES [H]C1(CCC(=O)CC1)C1CCC2(CC1)OCCO2

Description

This spirocyclic ketone features a rigid, fused dioxane-cyclohexanone framework that imparts exceptional conformational control. The 1,4-dioxaspiro[4.5]decan-8-yl moiety delivers enhanced stability and solubility in polar aprotic solvents, enabling efficient incorporation into complex molecular architectures.

Application

4-(1,4-Dioxaspiro[4.5]decan-8-yl)cyclohexanone serves as a versatile bicyclic building block in synthetic organic chemistry, enabling the construction of complex polycyclic frameworks through standard carbonyl transformations and ring-opening reactions. Its spirocyclic architecture provides defined stereochemistry and rigidity, facilitating controlled functionalization at the cyclohexanone moiety. The molecule exhibits bench stability and compatibility with common protecting group strategies, supporting efficient synthesis of natural product analogs and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • WO2006/118014 A1, ; Page/Page column 9-11 ;

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H412
Precautionary Statements : P261-P272-P273-P280-P302+P352-P363-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   2.679
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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