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CS-W001157 4
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tert-Butyl thiophen-2-ylcarbamate

  • CAS No. 56267-50-6

  • Cat. No. CS-W002949
  • Purity≥96%
  • MDL No.MFCD02677742

*For research and further manufacturing use only, not for direct human use.

tert-Butyl thiophen-2-ylcarbamate|CS-W002949

Structure of 56267-50-6

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General Information

  • CAS No. 56267-50-6
  • Cat. No. CS-W002949
  • Purity ≥96%
  • MDL No. MFCD02677742
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO₂S
  • Molecular Weight 199.27
  • Synonym(s) THIOPHEN-2-YL-CARBAMIC ACID TERT-BUTYL ESTER
  • SMILES O=C(OC(C)(C)C)Nc1cccs1

Description

tert-Butyl thiophen-2-ylcarbamate features a bench-stable carbamate group that enables straightforward deprotection under mild acidic conditions. The thiophenyl moiety provides enhanced solubility and electronic modulation, while the tert-butyl protecting group ensures compatibility with diverse synthetic transformations. This compound serves as a key intermediate in the synthesis of functionalized heterocycles and bioactive molecules.

Application

tert-Butyl thiophen-2-ylcarbamate serves as a stable, bench-friendly protecting group for primary amines, enabling selective functionalization in complex molecule synthesis. It exhibits excellent compatibility with diverse reaction conditions, facilitates straightforward deprotection under mild acidic conditions, and supports efficient incorporation into heterocyclic scaffolds and peptide-like architectures.

Synthesis

  • Route1
    • In-stock
      Rivaroxaban impurity 50|CS-W020070
      527-72-0
    • null|null
      75-65-0
    • ~92%
    • In-stock
      tert-Butyl thiophen-2-ylcarbamate|CS-W002949
      56267-50-6

    References

    • Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1594 - 1605
  • Route2

    References

    • Organic Letters, , vol. 7, # 22 p. 5087 - 5090
  • Route3
    • null|null
      110969-42-1
    • ~%
    • In-stock
      tert-Butyl thiophen-2-ylcarbamate|CS-W002949
      56267-50-6

    References

    • Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 41, # 1 p. 18 - 23

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   3.0951
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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