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CS-W001157 4
Total: USD 88.00

H-DL-Phe-OMe.HCl

  • CAS No. 5619-07-8

  • Cat. No. CS-W022742
  • Purity≥97%
  • MDL No.MFCD00066113

*For research and further manufacturing use only, not for direct human use.

H-DL-Phe-OMe.HCl|CS-W022742

Structure of 5619-07-8

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General Information

  • CAS No. 5619-07-8
  • Cat. No. CS-W022742
  • Purity ≥97%
  • MDL No. MFCD00066113
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄ClNO₂
  • Molecular Weight 215.68
  • Synonym(s) None
  • SMILES O=C(OC)C(N)CC1=CC=CC=C1.[H]Cl

Description

H-DL-Phe-OMe·HCl is a bench-stable, moisture-tolerant dipeptide building block featuring a methyl ester-protected phenylalanine residue. This synthetic intermediate integrates readily into peptide synthesis workflows, offering predictable coupling efficiency and enhanced solubility in common organic solvents.

Application

H-DL-Phe-OMe·HCl serves as a versatile, bench-stable building block for peptide synthesis and medicinal chemistry campaigns. The N-terminal H-DL-Phe-OMe moiety enables direct incorporation into peptidomimetics and heterocyclic scaffolds, while the hydrochloride salt ensures improved solubility and handling. Its functional group tolerance facilitates diverse coupling reactions and downstream modifications in standard synthetic workflows.

Synthesis

  • Route1

    References

    • Guo, Xiaoke; Yang, Qian; Xu, Jing; Zhang, Li; Chu, Hongxi; Yu, Peng; Zhu, Yingying; Wei, Jinglian; Chen, Weilin; Zhang, Yaozhong; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6466 - 6476
  • Route2
    • null|null
      67-56-1
    • In-stock
      DL-3-Phenylalanine|CS-W018529
      150-30-1
    • ~99%
    • In-stock
      H-DL-Phe-OMe.HCl|CS-W022742
      5619-07-8

    References

    • Kaptein, Bernard; Noorduin, Wim L.; Meekes, Hugo; Van Enckevort, Willem J. P.; Kellogg, Richard M.; Vlieg, Elias Angewandte Chemie - International Edition, 2008 , vol. 47, # 38 p. 7226 - 7229
  • Route3
    • null|null
      100020-81-3
    • ~85%
    • In-stock
      H-DL-Phe-OMe.HCl|CS-W022742
      5619-07-8

    References

    • Portelli, Mario Gazzetta Chimica Italiana, 1989 , vol. 119, # 4 p. 215 - 216

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.1512
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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