(5-Fluoropyridin-2-yl)methanamine

Name: (5-Fluoropyridin-2-yl)methanamine
Brand: ChemScene
Availability: InStock
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CAS No. 561297-96-9
Cat. No. CS-0112635
Purity≥95%
MDL No.MFCD10697659

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(5-Fluoropyridin-2-yl)methanamine|CS-0112635

Structure of 561297-96-9

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General Information

CAS No. 561297-96-9
Cat. No. CS-0112635
Purity ≥95%
MDL No. MFCD10697659
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇FN₂
Molecular Weight None
Synonym(s) 2-Pyridinemethanamine,5-fluoro-(9CI)
SMILES NCC1=NC=C(F)C=C1

Description

This fluoropyridylmethanamine integrates a strategically positioned fluorine atom and primary amine group, enabling direct functionalization in medicinal chemistry. The electron-deficient pyridine ring enhances reactivity in cross-coupling processes, while the pendant amine facilitates conjugation or salt formation for improved solubility and handling under standard conditions.

Application

(5-Fluoropyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its pyridine nitrogen and fluorine substituent provide orthogonal reactivity and enhanced metabolic stability, facilitating efficient derivatization. The primary amine group offers high functional group tolerance and enables straightforward purification via salt formation, making it well-suited for scalable synthesis and API development workflows.

Synthesis

Route1
- In-stock
  
  327056-62-2
- ~43%
- In-stock
  
  561297-96-9
References
- ELI LILLY AND COMPANY Patent: WO2005/66126 A1, 2005 ; Location in patent: Page/Page column 76 ; WO 2005/066126 A1
Route2
- 1228788-31-5
- ~%
- In-stock
  
  561297-96-9
References
- MERCK SHARP and DOHME CORP.; RAGHAVAN, Subharekha; STELMACH, John, E.; SMITH, Cameron, J.; LI, Hong; WHITEHEAD, Alan; WADDELL, Sherman, T.; CHEN, Yi-Heng; MIAO, Shouwu; ORNOSKI, Olga, A.; GARFUNKLE, Joie; LIAO, Xibin; CHANG, Jiang; HAN, Xiaoqing; GUO, Jian; GROEPER, Jonathan, A.; BROCKUNIER, Linda, L.; ROSAUER, Keith; PARMEE, Emma, R. Patent: WO2011/149921 A1, 2011 ; Location in patent: Page/Page column 90; 91 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 0.6794
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(5-Fluoropyridin-2-yl)methanamine

CAS No. 561297-96-9

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