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CS-W001157 4
Total: USD 88.00

(R)-1-Benzylpyrrolidine-2-carboxylic acid

  • CAS No. 56080-99-0

  • Cat. No. CS-0053504
  • Purity≥95%
  • MDL No.MFCD06656733

*For research and further manufacturing use only, not for direct human use.

(R)-1-Benzylpyrrolidine-2-carboxylic acid|CS-0053504

Structure of 56080-99-0

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General Information

  • CAS No. 56080-99-0
  • Cat. No. CS-0053504
  • Purity ≥95%
  • MDL No. MFCD06656733
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES OC(=O)[C@H]1CCCN1CC1=CC=CC=C1

Description

(R)-1-Benzylpyrrolidine-2-carboxylic acid is a chiral building block featuring a stereodefined pyrrolidine core with a benzyl-substituted alpha carbon. This configuration imparts enhanced selectivity in asymmetric synthesis, particularly in peptide mimetics and bioactive compound development. The molecule exhibits favorable solubility in organic solvents and stability under standard bench conditions, enabling straightforward incorporation into complex molecular architectures.

Application

(R)-1-Benzylpyrrolidine-2-carboxylic acid serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to bioactive heterocycles and peptidomimetics. Its well-defined stereochemistry and bench-stable nature facilitate straightforward functionalization, including amide coupling and decarboxylation reactions. The benzylic group enhances solubility and provides a handle for further derivatization, making it ideal for scaffold diversification in drug discovery campaigns.

Synthesis

  • Route1
    • null|null
      100-44-7
    • In-stock
      (R)-pyrrolidine-2-carboxylic acid|CS-W020557
      344-25-2
    • ~80%
    • In-stock
      (R)-1-Benzylpyrrolidine-2-carboxylic acid|CS-0053504
      56080-99-0

    References

    • ESTECHPHARMA CO., LTD. Patent: JP2005/247828 A, 2005 ; Location in patent: Page/Page column 15-16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.7356
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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