6-Chloro-5-nitro-2-picoline

Name: 6-Chloro-5-nitro-2-picoline
Brand: ChemScene
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CAS No. 56057-19-3
Cat. No. CS-0007518
Purity≥98%
MDL No.MFCD03085820

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 56057-19-3

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General Information

CAS No. 56057-19-3
Cat. No. CS-0007518
Purity ≥98%
MDL No. MFCD03085820
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₂O₂
Molecular Weight 172.57
Synonym(s) 2-Chloro-6-methyl-3-nitropyridine; 6-Chloro-5-nitro-2-picoline
SMILES O=[N+](C1=CC=C(C)N=C1Cl)[O-]

Description

6-Chloro-5-nitro-2-picoline features a chlorinated pyridine core with complementary nitro and methyl substituents, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient aromatic ring facilitates nucleophilic substitution reactions under mild conditions, while the para-oriented nitro group enhances reactivity in cross-coupling processes. This bench-stable compound serves as a key intermediate for advanced pharmaceutical and agrochemical synthesis.

Application

6-Chloro-5-nitro-2-picoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring due to orthogonal reactivity of the chloro and nitro groups. The chloro substituent facilitates palladium-catalyzed cross-coupling reactions, while the nitro group supports subsequent reduction to an amino moiety, offering access to diverse heterocyclic scaffolds. Its bench-stable nature and compatibility with standard purification methods make it well-suited for multi-step synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 56.03
LogP 1.95162
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-5-nitro-2-picoline

CAS No. 56057-19-3

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