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CS-W001157 4
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(3-(tert-Butyl)phenyl)boronic acid

  • CAS No. 560132-24-3

  • Cat. No. CS-0102096
  • Purity≥96%
  • MDL No.MFCD11110647

*For research and further manufacturing use only, not for direct human use.

(3-(tert-Butyl)phenyl)boronic acid|CS-0102096

Structure of 560132-24-3

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General Information

  • CAS No. 560132-24-3
  • Cat. No. CS-0102096
  • Purity ≥96%
  • MDL No. MFCD11110647
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅BO₂
  • Molecular Weight 178.04
  • Synonym(s) 3-Tert-butylphenylboronic acid
  • SMILES OB(O)C1=CC=CC(C(C)(C)C)=C1

Description

This boronate moiety features a sterically hindered tert-butyl group that enhances stability and solubility in organic media. It integrates readily into Suzuki-Miyaura coupling reactions under standard conditions, enabling efficient C–C bond formation with aryl halides. The para-substituted phenyl ring provides electronic tuning for controlled reactivity.

Application

(3-(tert-Butyl)phenyl)boronic acid serves as a robust building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. Its tert-butyl substituent enhances steric stability and improves bench storage longevity. The boronic acid functionality exhibits high functional group tolerance and facilitates straightforward purification via crystallization or flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.6639
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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