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CS-W001157 4
Total: USD 88.00

4-(4-Nitrophenyl)butanoic acid

  • CAS No. 5600-62-4

  • Cat. No. CS-W015167
  • Molecule weight209.20
  • Purity≥98%
  • MDL No.MFCD00007387

*For research and further manufacturing use only, not for direct human use.

4-(4-Nitrophenyl)butanoic acid|CS-W015167

Structure of 5600-62-4

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General Information

  • CAS No. 5600-62-4
  • Cat. No. CS-W015167
  • Purity ≥98%
  • MDL No. MFCD00007387
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₄
  • Molecular Weight 209.20
  • Synonym(s) N-(3-acetylphenyl)-N~2~-[(2-nitrophenyl)sulfonyl]-N~2~-phenylglycinamide
  • SMILES O=C(O)CCCC1=CC=C([N+]([O-])=O)C=C1

Description

4-(4-Nitrophenyl)butanoic acid features a conjugated aryl-alkyl linker with a terminal carboxylic acid, enabling direct integration into peptide coupling and polymer functionalization workflows. The para-nitro group enhances electron-withdrawing character, stabilizing reaction intermediates under standard conditions. This bench-stable derivative supports efficient synthesis of bioconjugates and advanced materials.

Application

4-(4-Nitrophenyl)butanoic acid serves as a versatile building block for conjugated aromatic systems, enabling efficient access to functionalized aliphatic chains via standard esterification, amidation, and reduction protocols. Its robust bench stability and compatibility with diverse reaction conditions facilitate downstream synthesis of pharmaceutical intermediates and advanced materials.

Synthesis

  • Route1

    References

    • Webb, Kevin S.; Seneviratne, Viran Tetrahedron Letters, 1995 , vol. 36, # 14 p. 2377 - 2378
  • Route2
    • In-stock
      4-Phenylbutyric acid|CS-D1686
      1821-12-1
    • ~22%
    • 4-(2-Nitrophenyl)butanoic acid|CS-0580375
      67857-97-0
    • In-stock
      4-(4-Nitrophenyl)butanoic acid|CS-W015167
      5600-62-4

    References

    • Journal of Pharmaceutical Sciences, , vol. 77, # 2 p. 185 - 187
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 70, p. 3177

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   80.44
  • LogP   2.0021
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   5

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