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CS-W001157 4
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1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane

  • CAS No. 56-33-7

  • Cat. No. CS-0158130
  • Purity≥98%
  • MDL No.MFCD00039793

*For research and further manufacturing use only, not for direct human use.

1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane|CS-0158130

Structure of 56-33-7

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General Information

  • CAS No. 56-33-7
  • Cat. No. CS-0158130
  • Purity ≥98%
  • MDL No. MFCD00039793
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₂OSi₂
  • Molecular Weight 286.52
  • Synonym(s) 1,3-Diphenyltetramethyldisiloxane; 1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane
  • SMILES C[Si](C)(C1=CC=CC=C1)O[Si](C)(C)C2=CC=CC=C2

Description

This disiloxane features two phenyl rings flanking a Si–O–Si backbone, offering enhanced thermal stability and steric protection. The tetramethyl substitution minimizes reactivity while improving solubility in nonpolar solvents. It serves as a robust scaffold in organosilicon synthesis and silicone polymer modification, enabling controlled functionalization under mild conditions.

Application

1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane serves as a stable, bench-friendly silylating agent that facilitates the protection of alcohols and carboxylic acids under mild conditions. Its steric bulk enhances selectivity and minimizes side reactions, while the diphenylsilyl moiety enables efficient removal with fluoride sources. The compound offers excellent functional group tolerance and simplifies purification in complex synthetic sequences.

Synthesis

  • Route1
    • null|null
      124-38-9
    • null|null
      766-77-8
    • ~9%
    • In-stock
      1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane|CS-0158130
      56-33-7

    References

    • Itagaki, Shintaro; Yamaguchi, Kazuya; Mizuno, Noritaka Journal of Molecular Catalysis A: Chemical, 2013 , vol. 366, p. 347 - 352
  • Route2
    • null|null
      17908-86-0
    • ~53%
    • In-stock
      1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane|CS-0158130
      56-33-7
    • null|null
      108-88-3

    References

    • Igarashi, Masayasu; Matsumoto, Tomohiro; Sato, Kazuhiko; Ando, Wataru; Shimada, Shigeru Chemistry Letters, 2014 , vol. 43, # 4 p. 429 - 431
  • Route3
    • null|null
      768-33-2
    • ~87%
    • In-stock
      1,1,3,3-Tetramethyl-1,3-diphenyldisiloxane|CS-0158130
      56-33-7

    References

    • Fleming, Ian; Roberts, Richard S.; Smith, Stephen C. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 7 p. 1209 - 1214

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.2276
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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