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CS-W001157 4
Total: USD 88.00

Ethyl 2-fluoro-2-methylpropanoate

  • CAS No. 55816-69-8

  • Cat. No. CS-0312272
  • Purity≥97%
  • MDL No.MFCD08062432

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-fluoro-2-methylpropanoate|CS-0312272

Structure of 55816-69-8

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General Information

  • CAS No. 55816-69-8
  • Cat. No. CS-0312272
  • Purity ≥97%
  • MDL No. MFCD08062432
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁FO₂
  • Molecular Weight 134.15
  • Synonym(s) Ethyl 2-fluoroisobutyrate
  • SMILES CC(C)(F)C(OCC)=O

Description

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Primary amines readily form amides with carboxylic acids in the presence of activator reagents such as HATU or EDC, while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Synthesis

  • Route1
    • null|null
      80-55-7
    • ~86%
    • Ethyl 2-fluoro-2-methylpropanoate|CS-0312272
      55816-69-8

    References

    • Lal, Gauri S.; Pez, Guido P.; Pesaresi, Reno J.; Prozonic, Frank M.; Cheng, Hansong Journal of Organic Chemistry, 1999 , vol. 64, # 19 p. 7048 - 7054
  • Route2

    References

    • US5250686 A1, ;
  • Route3
    • null|null
      349-43-9
    • null|null
      74-88-4
    • ~%
    • Ethyl 2-fluoro-2-methylpropanoate|CS-0312272
      55816-69-8

    References

    • US5750778 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅱ
Hazard Statements : H225-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.2976
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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