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CS-W001157 4
Total: USD 88.00

(tert-Butoxycarbonyl)-L-phenylalanyl-L-alanine

  • CAS No. 55677-48-0

  • Cat. No. CS-0101216
  • Purity≥97%
  • MDL No.MFCD00190818

*For research and further manufacturing use only, not for direct human use.

(tert-Butoxycarbonyl)-L-phenylalanyl-L-alanine|CS-0101216

Structure of 55677-48-0

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General Information

  • CAS No. 55677-48-0
  • Cat. No. CS-0101216
  • Purity ≥97%
  • MDL No. MFCD00190818
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₄N₂O₅
  • Molecular Weight 336.38
  • Synonym(s) None
  • SMILES C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC(OC(C)(C)C)=O)=O

Description

Boc-L-Phe-Ala delivers a protected dipeptide scaffold for peptide synthesis, featuring a bench-stable tert-butoxycarbonyl group that enables selective N-terminal capping. This orthogonal protection supports efficient coupling and deprotection sequences in complex peptide assembly workflows.

Application

Boc-L-Phe-Ala-OH serves as a key dipeptide building block in peptide synthesis, offering robust protection of the N-terminus via the Boc group and stable C-terminal carboxylic acid functionality. Its bench-stable nature facilitates straightforward handling, efficient coupling reactions, and clean purification—ideal for sequential assembly of larger peptides and peptidomimetics in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      885623-82-5
    • ~78%
    • In-stock
      (tert-Butoxycarbonyl)-L-phenylalanyl-L-alanine|CS-0101216
      55677-48-0

    References

    • Fustero, Santos; Sancho, Amador Garcia; Chiva, Gema; Sanz-Cervera, Juan F.; Del Pozo, Carlos; Acena, Jose Luis Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3299 - 3302
  • Route2
    • L-Alanine Enalapril  Impurity|CS-0229434
      56-41-7
    • null|null
      514214-66-5
    • ~95%
    • In-stock
      (tert-Butoxycarbonyl)-L-phenylalanyl-L-alanine|CS-0101216
      55677-48-0

    References

    • Katritzky, Alan R.; Suzuki, Kazuyuki; Singh, Sandeep K. Synthesis, 2004 , # 16 p. 2645 - 2652
  • Route3

    References

    • Popovic, Stanimir; Bieraeugel, Hans; Detz, Remko J.; Kluwer, Alexander M.; Koole, Jelmer A. A.; Streefkerk, Dieuwertje E.; Hiemstra, Henk; Van Maarseveen, Jan H. Chemistry - A European Journal, 2013 , vol. 19, # 50 p. 16934 - 16937

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   104.73
  • LogP   1.7117
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   6

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