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CS-W001157 4
Total: USD 88.00

1-((2R,4R,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

  • CAS No. 55612-11-8

  • Cat. No. CS-W011520
  • Purity≥98%
  • MDL No.MFCD00134202

*For research and further manufacturing use only, not for direct human use.

1-((2R,4R,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione|CS-W011520

Structure of 55612-11-8

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General Information

  • CAS No. 55612-11-8
  • Cat. No. CS-W011520
  • Purity ≥98%
  • MDL No. MFCD00134202
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₂₈N₂O₅
  • Molecular Weight 484.54
  • Synonym(s) 5-O-Trityl-2-Deoxy-Beta-D-Lyxofuranosylthymine
  • SMILES O[C@@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

Synthesis

  • Route1
    • 5'-O-Trityl-3'-O-mesylthymidine|CS-1659473
      42214-24-4
    • ~64%
    • 1-((2R,4R,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione|CS-W011520
      55612-11-8

    References

    • Srivastav, Naveen C.; Shakya, Neeraj; Mak, Michelle; Agrawal, Babita; Tyrrell, D. Lorne; Kumar, Rakesh Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7156 - 7166
  • Route2
    • null|null
      141690-73-5
    • ~89%
    • 1-((2R,4R,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione|CS-W011520
      55612-11-8

    References

    • Wilson, I. K.; Chatterjee, S.; Wolf, W. Journal of Fluorine Chemistry, 1991 , vol. 55, # 3 p. 283 - 289
  • Route3
    • 5'-O-Trityl-3'-O-mesylthymidine|CS-1659473
      42214-24-4
    • ~20%
    • null|null
      909256-85-5
    • 1-((2R,4R,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione|CS-W011520
      55612-11-8

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 3 p. 249 - 256

Safety Information

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GHS Pictogram : N/A
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Signal Word : N/A
UN#: N/A
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Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   93.55
  • LogP   3.50212
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   7

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