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7-Fluorobenzo[b]thiophene-2-carboxylic acid

  • CAS No. 550998-67-9

  • Cat. No. CS-0129396
  • Molecule weight196.20
  • Purity≥98%
  • MDL No.MFCD07377074

*For research and further manufacturing use only, not for direct human use.

7-Fluorobenzo[b]thiophene-2-carboxylic acid|CS-0129396

Structure of 550998-67-9

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General Information

  • CAS No. 550998-67-9
  • Cat. No. CS-0129396
  • Purity ≥98%
  • MDL No. MFCD07377074
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅FO₂S
  • Molecular Weight 196.20
  • Synonym(s) None
  • SMILES O=C(C1=CC2=CC=CC(F)=C2S1)O

Description

7-Fluorobenzo[b]thiophene-2-carboxylic acid features a fluorinated benzothiophene core with a carboxylic acid group at the 2-position, delivering enhanced electronic modulation and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for kinase inhibitors and CNS-targeted therapeutics.

Application

7-Fluorobenzo[b]thiophene-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the carboxylic acid group enables direct coupling reactions or derivatization. The compound exhibits good bench stability and facilitates efficient functionalization in standard amide, ester, and Suzuki-type transformations.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.7386
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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