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CS-W001157 4
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1,7-Naphthyridin-2(1H)-one

  • CAS No. 54920-82-0

  • Cat. No. CS-0135920
  • Molecule weight146.15
  • Purity≥98%
  • MDL No.MFCD11521584

*For research and further manufacturing use only, not for direct human use.

1,7-Naphthyridin-2(1H)-one|CS-0135920

Structure of 54920-82-0

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General Information

  • CAS No. 54920-82-0
  • Cat. No. CS-0135920
  • Purity ≥98%
  • MDL No. MFCD11521584
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 1H-1,7-naphthyridin-2-one
  • SMILES O=C1NC2=CN=CC=C2C=C1

Description

1,7-Naphthyridin-2(1H)-one features a fused bicyclic core with nitrogen atoms at strategic positions, enabling strong hydrogen bonding and enhanced solubility in polar solvents. This scaffold serves as a privileged heterocyclic framework in medicinal chemistry, particularly for kinase inhibitors and DNA-targeting agents. The molecule exhibits good stability under standard bench conditions and integrates readily into multi-step synthetic sequences.

Application

1,7-Naphthyridin-2(1H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to bioactive molecules through established functionalization at C3 and C6 positions. Its planar structure and hydrogen-bonding capacity support robust ligand-receptor interactions. The compound exhibits bench stability and compatibility with standard coupling reactions, facilitating integration into diverse synthetic sequences for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   0.9231
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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