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CS-W001157 4
Total: USD 88.00

(5-Chlorothiophen-2-yl)methanamine hydrochloride

  • CAS No. 548772-41-4

  • Cat. No. CS-0053153
  • Molecule weight184.09
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Chlorothiophen-2-yl)methanamine hydrochloride|CS-0053153

Structure of 548772-41-4

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General Information

  • CAS No. 548772-41-4
  • Cat. No. CS-0053153
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇Cl₂NS
  • Molecular Weight 184.09
  • Synonym(s) 2-Aminomethyl-5-chlorothiophene hydrochloride
  • SMILES NCC1=CC=C(S1)Cl.Cl

Description

This bench-stable amine features a chlorothiophene scaffold that imparts enhanced electron-withdrawing character, enabling efficient coupling in cross-coupling and cyclization reactions. The hydrochloride salt improves solubility and handling, facilitating integration into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

(5-Chlorothiophen-2-yl)methanamine hydrochloride serves as a versatile building block for heterocyclic synthesis, enabling direct incorporation of a chlorothiophene moiety into biologically relevant scaffolds. The amine functionality facilitates facile coupling reactions and derivatization under standard conditions, while the hydrochloride salt ensures excellent bench stability and ease of handling. Its functional group tolerance supports integration into diverse synthetic routes for pharmaceutical intermediates and agrochemicals.

Synthesis

  • Route1

    References

    • Yu, Guixue; Mason, Helen J.; Galdi, Kim; Wu, Ximao; Cornelius, Lyndon; Zhao, Ning; Witkus, Michael; Ewing, William R.; Macor, John E. Synthesis, 2003 , # 3 p. 403 - 407

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.282
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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