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CS-W001157 4
Total: USD 88.00

1,2-Oxazinane HYDROCHLORIDE Salt

  • CAS No. 54722-74-6

  • Cat. No. CS-W000777
  • Molecule weight123.58
  • Purity≥97%
  • MDL No.MFCD13193208

*For research and further manufacturing use only, not for direct human use.

1,2-Oxazinane HYDROCHLORIDE Salt|CS-W000777

Structure of 54722-74-6

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General Information

  • CAS No. 54722-74-6
  • Cat. No. CS-W000777
  • Purity ≥97%
  • MDL No. MFCD13193208
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClNO
  • Molecular Weight 123.58
  • Synonym(s) oxazinan-2-ium
  • SMILES Cl.C1CCONC1

Description

1,2-Oxazinane hydrochloride is a bench-stable heterocyclic compound featuring a saturated oxazinane ring with a protonated nitrogen. This structure delivers enhanced solubility in aqueous media and facilitates efficient coupling reactions under mild conditions. The hydrochloride salt form improves handling and storage stability, making it well-suited for synthetic applications in medicinal chemistry and peptide derivatization workflows.

Application

1,2-Oxazinane hydrochloride serves as a stable, bench-ready synthon for the construction of nitrogen-containing heterocycles. Its amine functionality enables straightforward alkylation and acylation, while the oxazinane ring provides compatibility with diverse reaction conditions. The hydrochloride salt enhances solubility and handling, facilitating purification and integration into multi-step synthetic sequences. Functions effectively in the synthesis of bioactive scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1
    • tert-Butyl oxazinane-2-carboxylate|CS-0037744
      664364-75-4
    • ~%
    • In-stock
      1,2-Oxazinane HYDROCHLORIDE Salt|CS-W000777
      54722-74-6

    References

    • Takeda Pharmaceutical Company Limited Patent: EP1553074 A1, 2005 ; Location in patent: Page/Page column 47 ;
  • Route2
    • null|null
      54463-32-0
    • ~%
    • In-stock
      1,2-Oxazinane HYDROCHLORIDE Salt|CS-W000777
      54722-74-6

    References

    • Bhat, J. Ishwara; Clegg, William; Maskill, Howard; Elsegood, Mark R.J.; Menneer, Iain D.; Miatt, Peter C. Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1435 - 1446

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.7232
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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