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Structure of 54718-39-7
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2,5,6-Trichloronicotinic acid is a highly electron-deficient heterocyclic carboxylic acid featuring three chlorine substituents at the 2, 5, and 6 positions of the nicotinic ring. This arrangement enhances its reactivity in cross-coupling processes and facilitates incorporation into bioactive scaffolds requiring strong electron-withdrawing functionality. The compound exhibits robust stability under standard bench conditions and integrates efficiently into synthetic sequences demanding halogenated building blocks.
2,5,6-Trichloronicotinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a highly functionalized pyridine core with orthogonal reactivity. Its three chlorine substituents enable selective nucleophilic substitution or transition-metal-catalyzed coupling reactions, facilitating rapid diversification of heterocyclic scaffolds. The carboxylic acid group provides a handle for amide formation, esterification, or salt generation, enhancing solubility and processability. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows requiring halogenated nitrogen heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: