Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Chloropyrimidin-5-amine

  • CAS No. 54660-78-5

  • Cat. No. CS-W005614
  • Purity≥97%
  • MDL No.MFCD06412561

*For research and further manufacturing use only, not for direct human use.

4-Chloropyrimidin-5-amine|CS-W005614

Structure of 54660-78-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 54660-78-5
  • Cat. No. CS-W005614
  • Purity ≥97%
  • MDL No. MFCD06412561
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClN₃
  • Molecular Weight 129.55
  • Synonym(s) 5-pyrimidinamine, 4-chloro-
  • SMILES NC1=CN=CN=C1Cl

Description

4-Chloropyrimidin-5-amine serves as a key heterocyclic building block in medicinal chemistry, featuring a chlorine substituent at the 4-position and an amine group at the 5-position. This combination enables direct coupling in cross-coupling reactions and facilitates rapid diversification of pyrimidine-based scaffolds. The compound exhibits good stability under standard conditions and integrates readily into kinase inhibitor and antiviral lead candidates.

Application

4-Chloropyrimidin-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its reactive chloro group facilitates nucleophilic substitution with amines, thiols, and other heteroatoms, while the pendant amine supports further functionalization. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, making it ideal for modular synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1
    • 5-Amino-6-chloropyrimidine-4-thiol|CS-0453489
      54851-35-3
    • ~45%
    • In-stock
      4-Chloropyrimidin-5-amine|CS-W005614
      54660-78-5

    References

    • ELAN PHARMACEUTICALS, INC. Patent: WO2007/8563 A2, 2007 ; Location in patent: Page/Page column 88 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.7122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Chloropyrimidin-5-amine sigma4-Chloropyrimidin-5-amine manufacturer4-Chloropyrimidin-5-amine price4-Chloropyrimidin-5-amine structure4-Chloropyrimidin-5-amine SDSbuy 4-Chloropyrimidin-5-amine4-Chloropyrimidin-5-amine supplier4-Chloropyrimidin-5-amine uses4-Chloropyrimidin-5-amine molecular weightprice of 4-Chloropyrimidin-5-amine4-Chloropyrimidin-5-amine chemical name formula of 4-Chloropyrimidin-5-amine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label