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CS-W001157 4
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Diethyl (2-amino-2-oxoethyl)phosphonate

  • CAS No. 5464-68-6

  • Cat. No. CS-0129422
  • Purity≥97%
  • MDL No.MFCD00014805
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

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*For research and further manufacturing use only, not for direct human use.

Diethyl (2-amino-2-oxoethyl)phosphonate|CS-0129422

Structure of 5464-68-6

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Description

Diethyl (2-amino-2-oxoethyl)phosphonate features a phosphonate group flanked by ethyl esters and a β-amino ketone motif, enabling direct incorporation into peptide mimetics and bioactive phosphonates. This bench-stable derivative facilitates efficient synthesis of protease inhibitors and transition-state analogs under standard conditions.

Application

Diethyl (2-amino-2-oxoethyl)phosphonate serves as a versatile building block in synthetic organic chemistry, enabling the construction of phosphonate-containing heterocycles and peptide mimetics. Its amino and carbonyl functionalities support diverse transformations, including condensation, cyclization, and metal-catalyzed coupling reactions. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and catalyst development.

General Information

  • CAS No. 5464-68-6
  • Cat. No. CS-0129422
  • Purity ≥97%
  • MDL No. MFCD00014805
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄NO₄P
  • Molecular Weight 195.15
  • Synonym(s) Phosphonic acid, (carbamoylmethyl)-, diethyl ester
  • SMILES O=C(N)CP(OCC)(OCC)=O

Computational Chemistry Data

  • TPSA   78.62
  • LogP   0.7378
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P264-P280-P305+P351+P338-P337+P313

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