Cyclobutylmethanamine hydrochloride

Name: Cyclobutylmethanamine hydrochloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 5454-82-0
Cat. No. CS-W004986
Purity≥97%
MDL No.MFCD00034952

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Cyclobutylmethanamine hydrochloride|CS-W004986

Structure of 5454-82-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 5454-82-0
Cat. No. CS-W004986
Purity ≥97%
MDL No. MFCD00034952
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₂ClN
Molecular Weight 121.61
Synonym(s) Cyclobutanemethanamine,hydrochloride (9CI)
SMILES NCC1CCC1.Cl

Description

Cyclobutylmethanamine hydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a constrained cyclobutyl ring fused to a methylene linker. This rigid scaffold imparts enhanced metabolic stability and favorable lipophilicity, enabling efficient integration into bioactive molecule design. The hydrochloride salt ensures high solubility in aqueous systems and simplifies handling in synthetic workflows.

Application

Cyclobutylmethanamine hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through amine functionalization. Its cyclobutylmethyl motif provides enhanced metabolic stability and conformational rigidity compared to linear analogs. The hydrochloride salt ensures excellent bench stability, ease of handling, and straightforward purification. It participates reliably in reductive amination, acylation, and coupling reactions, facilitating efficient access to diverse heterocyclic and peptide-like architectures in lead optimization campaigns.

Synthesis

Route1
- 4426-11-3
- ~15%
- In-stock
  
  5454-82-0
References
- GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth Patent: WO2011/97491 A1, 2011 ; Location in patent: Page/Page column 71-72 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 26.02
LogP 1.167
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

Cyclobutylmethanamine hydrochloride sigmaCyclobutylmethanamine hydrochloride manufacturerCyclobutylmethanamine hydrochloride priceCyclobutylmethanamine hydrochloride structureCyclobutylmethanamine hydrochloride SDSbuy Cyclobutylmethanamine hydrochlorideCyclobutylmethanamine hydrochloride supplierCyclobutylmethanamine hydrochloride usesCyclobutylmethanamine hydrochloride molecular weightprice of Cyclobutylmethanamine hydrochlorideCyclobutylmethanamine hydrochloride chemical name formula of Cyclobutylmethanamine hydrochloride

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Cyclobutylmethanamine hydrochloride

CAS No. 5454-82-0

Recommended Products