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CS-W001157 4
Total: USD 88.00

1,3-Bis(4-bromophenyl)propan-2-one

  • CAS No. 54523-47-6

  • Cat. No. CS-0322943
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3-Bis(4-bromophenyl)propan-2-one|CS-0322943

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General Information

  • CAS No. 54523-47-6
  • Cat. No. CS-0322943
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₂Br₂O
  • Molecular Weight 368.06
  • Synonym(s) 4,4'-Dibromodibenzyl Ketone
  • SMILES C1=C(C=CC(=C1)Br)CC(=O)CC2=CC=C(C=C2)Br

Description

1,3-Bis(4-bromophenyl)propan-2-one features two para-brominated phenyl groups flanking a ketone-bearing propan-2-one backbone. This electron-deficient scaffold enables direct integration into cross-coupling reactions and serves as a robust building block for conjugated molecular architectures in materials science and synthetic organic chemistry.

Application

1,3-Bis(4-bromophenyl)propan-2-one serves as a versatile building block in the synthesis of biaryl-containing scaffolds and functionalized ketones. Its dual bromophenyl groups enable efficient cross-coupling reactions, while the central ketone functions as a key electrophilic site for nucleophilic additions and condensation processes. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Doklady Chemistry, , vol. 442, # 2 p. 23 - 29
  • Route2

    References

    • Tetrahedron Letters, , vol. 24, # 37 p. 4005 - 4008
  • Route3

    References

    • Organic Letters, , vol. 9, # 7 p. 1187 - 1190

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   4.5659
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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